2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113322
    3-Hydroxyquinine 53467-23-5 98%
    3-Hydroxyquinine is a metabolite of Quinidine (HY-B1751). 3-Hydroxyquinine prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in an isolated rat heart reperfusion arrhythmia model in a concentration-dependent manner. 3-Hydroxyquinine can be used in the study of cardiac arrhythmias.
    3-Hydroxyquinine
  • HY-113375
    D-Ribofuranose 613-83-2 98%
    D-Ribofuranose (D-Ribose) is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Ribose 5 Phosphate Isomerase Deficiency and Medium Chain Acyl Co A Dehydrogenase Deficiency.
    D-Ribofuranose
  • HY-113444
    Prostaglandin D3 71902-47-1 98%
    Prostaglandin D3 (PGD3) is a prostaglandin that acts as an inhibitor of platelet aggregation and a modulator of autonomic neurotransmission in humans.
    Prostaglandin D3
  • HY-113641
    ROCK-IN-32 1013117-40-2 98%
    ROCK-IN-32 is a ROCK inhibitor, with an IC50 value of 11 nM for ROCK2. ROCK-IN-32 can be used in research of cardiovascular disease, cancer and inflammation.
    ROCK-IN-32
  • HY-113681
    REV 5975 101820-46-6 98%
    REV 5975 is a angiotensin converting enzyme (ACE) inhibitor. REV 5975 shows a partial reduction of the angiotensin I effect.
    REV 5975
  • HY-113695
    BW A575C 103221-88-1 98%
    BW A575C is a dual inhibitor against angiotensin converting enzyme (ACE) and β-adrenoceptor. BW A575C produces a competitive blockade of Isoprenaline (HY-108353)-induced tachycardia in a guinea-pig right atrial. BW A575C also inhibits Angiotensin I (HY-P1032)-induced pressor responses in rats. BW A575C is promising for research of hypertensive diseases.
    BW A575C
  • HY-113702
    PD 113413 103733-50-2 98%
    PD 113413 is formed by subsequent hydrolysis of the diketopiperazine quinapril analog. PD 113413 is a potent angiotensin-converting enzyme inhibitor. PD 113413 can be used for research of hypertension and congestive heart failure.
    PD 113413
  • HY-113847
    Nanterinone mesylate 102791-74-2 98%
    Nanterinone mesylate (UK-61260-27) is an orally active and positive inotropic and balanced-type vasodilating agent, partially based on phosphodiesterase III inhibition with venodilating properties. Nanterinone mesylate is promising for research of cardiovascular diseases.
    Nanterinone mesylate
  • HY-113898
    Ganoderic acid K 104700-95-0 98%
    Ganoderic acid K is a potent angiotensin converting enzyme inhibitor. Ganoderic acid K is a triterpene that can be found in ganoderma lucidum.
    Ganoderic acid K
  • HY-114029
    Ep vinyl quinidine 101143-87-7 98%
    Ep vinyl quinidine (3-Epiquinine) is an epi-vinyl stereoisomer of Quinidine. Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine can be used for malaria research.
    Ep vinyl quinidine
  • HY-114293
    Acetyl coenzyme A 72-89-9 98%
    Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis.
    Acetyl coenzyme A
  • HY-114424
    H-Ile-Pro-Pro-OH 26001-32-1 98%
    H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides.
    H-Ile-Pro-Pro-OH
  • HY-114538
    Asobamast 104777-03-9 98%
    Asobamast is a potent, orally active antiallergic agent that inhibits ige mediated passive pulmonary allergic responses in rats (ED50=4.7 mg/kg) and inhibits antigen-induced mediator release from sensitized guinea pig lung fragments.
    Asobamast
  • HY-114593
    ent-8-iso Prostaglandin F2α 159812-83-6 98%
    ent-8-iso Prostaglandin F2α (ent-15-F2t-IsoP) is a potent vasoconstrictor of porcine retina and cerebral microvessels with EC50 values of 30.6 and 53.5 nM, respectively.
    ent-8-iso Prostaglandin F2α
  • HY-114603
    Efegatran 105806-65-3 98%
    Efegatran (LY 294468) is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.
    Efegatran
  • HY-114630
    Protokylol 136-70-9 98%
    Protokylol (Caytine; JB-251) is a beta-adrenergic receptor agonist and TRPV1 agonist. Protokylol is used as a bronchodilator.
    Protokylol
  • HY-114643
    (Rac)-Tovinontrine 1430840-90-6 98%
    (Rac)-Tovinontrine ((Rac)-IMR-687) is a phosphodiesterase 9 (PDE9) inhibitor that increases cyclic guanosine monophosphate (cGMP) levels. (Rac)-Tovinontrine is promising for research of thalassemia.
    (Rac)-Tovinontrine
  • HY-114666
    Trimoxamine hydrochloride 7082-27-1 98%
    Trimoxamine hydrochloride (NDR-5523A) is an antihypertensive drug with hypotensive activity. Trimoxamine hydrochloride can be used to inhibit hypertension-related diseases. Trimoxamine hydrochloride lowers blood pressure by inhibiting vasoconstriction. Trimoxamine hydrochloride plays an important role in the management of cardiovascular diseases.
    Trimoxamine hydrochloride
  • HY-114687
    5,7-Dihydroxy-11-ketotetranorprostanoic acid 24379-94-0 98%
    5,7-Dihydroxy-11-ketotetranorprostanoic acid is a urinary metabolite of prostaglandin F2α and precursor to tetranor-PGF metabolites, exhibits hardly activity in blood pressure assay and smooth muscle stiumulation assay.
    5,7-Dihydroxy-11-ketotetranorprostanoic acid
  • HY-114751
    16,16-Dimethylprostaglandin E1 41692-15-3 98%
    16,16-Dimethylprostaglandin E1 (16,16-dimethyl-PGE1) is a PGE1 (HY-B0131) analog, induces bronchoconstrict and vascular smooth muscle contractions and suppresses the indomethacin induced cellular elongation.
    16,16-Dimethylprostaglandin E1
Cat. No. Product Name / Synonyms Application Reactivity